Paseo de la Reforma and Avenida Constituyentes are the main roads to access the district, and are subject to traffic jams.

This road was located on the present-day avenue that is known by the name of Cuajimalpa Arteaga and Salazar, traversing the Sierra de las Cruces mountains and continuing by the current route of the federal interstate highway that connects Mexico City to Toluca.

During the Porfiriato era, a steam tramline was built on the former royal road, which at first ended at Santa Fe, and later expanded to La Venta, Cuajimalpa, and San Ángel.

Contrary to what is said, from the northern edge of Santa Fe Shopping Center to the area of the colony was used as Pena Blanca dump, even on the side of Cuajimalpa with tunnels that cross to walk of Tamarind.

It was a mess that was duly closed and locked when President José López Portillo built his residential complex in the place popularly known as "Dog Hill".

In the early 1970s, an urban development plan was created for the area, which would be built in an industrial zone in the area to provide jobs to locals and develop import substitution, between what is planned consider creating the social rehabilitation center west "Ceres" like those built in the north, south and west of Mexico City.

As a result of the 1994 economic crisis in Mexico, the master plan was halted and it was not until 2000 when the first phase of Santa Fe City was reinstated.

The inadequate road infrastructure, energy, hydro power, which was originally planned for a residential zone, and residents, generated active participation in solving their basic problems, so they propose and manage a new organization where they create a sort of government procedure in which a special item given: the GDF without telling borough governments, leading to coordination problems.

The agreement invested amounts are a percentage of property tax and are subject to review and approval expressed by the technical committee as the highest authority of the trust and trustee, this is composed of 7 members of which 4 are appointed by the association and the 3 remaining the Federal District government and decisions are taken by majority vote and at least 1 of the GDF with the president casting vote in case of tie and extraordinarily many times as needed.

Jeffrey Inaba of Harvard University argued that Santa Fe should build connections to other parts of Mexico City.

Roque González, the author of the original Santa Fe development project, said in 2005 "in 15 years will be a serious problem due to the fact that there are insufficient roads, public spaces, pedestrian areas.

[13][citation needed] Road access from central Mexico City remains inadequate, with Paseo de la Reforma and Avenida Constituyentes both congested at peak hours.

Plans have been circulated to build a tunnel from the Circuito Interior in Condesa along Constituyentes to the point where it meets Reforma just before Santa Fe.

[15] Just west of Santa Fe, the Chamapa-La Venta toll road connects to the Interlomas edge city and points north.

[18] In late 2024 or early 2025, the area will be connected by the El Insurgente commuter rail system with a station located next to Centro Santa Fe.