Santa Fe High School is a high school serving grades 9–12 from the Alachua-High Springs area in the northwestern part of Alachua County, Florida.

Mebane Middle School to offer a track for students to become licensed and experienced to either continue their education at the Santa Fe College Perry Center for Emerging Technologies (also in Alachua), or enter the workforce in one of the several emerging technology companies located within the City; the Academy of AgriScience; and the Academy of Veterinary Assisting.

[10] The baseball team won the 1975 State Championship and was Runner-Up in 1972.

[15] The boys soccer team has won a total of three district championships in 2012, 2013, and 2019.

[16] The "Raider Regiment" marching band has won eight state championships, five consecutively from 1999 to 2003, then again in 2005, 2009 and 2010.