The Santa Fe Southern Railway (reporting mark SFSR) is a short line railroad in New Mexico, United States.

[2] On May 20, 2011, the railroad was evicted from its headquarters at the depot in Santa Fe to make way for a new visitors' center planned to serve New Mexico Rail Runner passengers.

The railroad's business fluctuated greatly; in 2004, it hauled 401 carloads of freight, and in 2007 carried 25,907 passengers, but in 2009 these counts decreased to 25 and 12,208, both record lows.

On May 23, 2013, the Santa Fe Southern board chairman announced that he had laid-off all of the railroad's full-time staffers and many seasonal employees.

[5] On April 24, 2014, the Las Vegas Railway Express (LVRE) announced that it had reached an agreement with the Santa Fe Southern to jointly operate excursion trains that summer.