1640) was a 17th-century Spanish mission believed by the Fernbank Museum of Natural History to be located in modern-day Telfair County, Georgia, near Jacksonville.
Operating for approximately two decades in the early 17th century, the mission was a religious outpost consisting of one Catholic friar sent out to convert and monitor the native people at the edges of the colony.
In April 2006 the Fernbank Museum of Natural History and Georgia Department of Natural Resources began three summer seasons of archeological excavation where the Ocmulgee and Oconee rivers converge to form the Altamaha River.
No evidence of the mission was found, and only Muskogean (proto-Creek) architecture and artifacts were uncovered, plus some trade items of probable Spanish origin.
In the 17th century the Spanish referred to the Altamaha River as the Rio de Santa Isabel, after the short-lived mission.