The church was restored by Pope Honorius I ca 630 in the vicinity of the monumental fountain lacus orphei.

[3] The deaconry was suppressed in 1587 by Pope Sixtus V.[4] In the 13th century, a monastery was attached to the church, enclosing it.

[citation needed] In 1534, it was given to the Benedictines, and in 1568 Pope Pius V granted it to the Augustinians, who still serve the church.

In 1878 the Italian state expropriated the convent of the Poor Clares, adjacent to San Lorenzo in Panisperna, but the nuns came to the monastery of Santa Lucia in Selci.

The barrel vault has a 19th-century fresco by an unknown artist that replaced one with the same motif by Giovanni Antonio Lelli, depicting the Glory of St Lucy.

The painting above the high altar depicting the Annunciation is a work of the Florentine painter Anastasio Fontebuoni.

[6] The Chapel of the Blessed Sacrament, the second on the left, contains works attributed to Carlo Maderno: a tabernacle in polychrome marble and gilt bronze and the alabaster statues.