José Agustín Molas was born in Santa María de Fe, one of the Catholic priests who took part in the independence revolution on 14 and 15 May 1811.

The French explorer and botanist, Amado Aimé Bonpland was detained in Santa María until 1829.

Whilst he was there, he taught the local population how to cultivate different plants and methods to produce candies and liquors.

The district of Santa María de Fe is located in the Eastern Region of Paraguay.

It's located 253 km south of Asuncion, the capital of the country, one arrives at Santa Maria, taking the National Route Number 1, and then taking a detour between the cities of San Ignacio and Santa Rosa.