The church of S. Maria Annunziata was founded in 1688 as the Oratory of the Archconfraternity of the nearby Ospedale di Santo Spirito in Sassia.

[1] In 1940, due to the opening of Via della Conciliazione, the oratory was dismantled and re-built ten years later in the present location facing the Tiber at the insistence of the Archconfraternity of the Holy Spirit who opposed the expropriation until they obtained the promise that the church would be rebuilt, identical to the original, in the immediate vicinity.

Among them, a detached fresco portraying the Virgin of the Milk with the Child, attributed to Antoniazzo Romano, and a lunette with the Apparition of St. Michael Archangel to Pope Gregory the Great.

[1] Next to the entrance is a statue of St. Michael the Archangel fighting with Lucifer", attributed to Louis-Albert Lefeuvre.

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