Santa Maria Immacolata all'Esquilino is a 20th-century parochial church and titular church on the Esquiline Hill in Rome, dedicated to the Mary Immaculate.

[3][4] Santa Maria Immacolata all'Esquilino was built in 1896–1914 in the Gothic Revival style for the Friars of Charity (Frati della Carità, Bigi).

[5] The Bigi broke up in 1973.

[6] In 2017, the church was purchased by the Society of Saint Pius X.

[5] On 28 June 2018, it was made a titular church to be held by a cardinal-deacon.