San Maria Maggiore is a Gothic-style, Roman Catholic parish church located on via San Maria Maggiore in the historic district of Civitanova of Lanciano, region of Abruzzi, Italy.
Construction was in place by 1227, commissioned by the emperor Frederick II, putatively erected atop a former temple of Apollo built inside a forest sacred to the ancient inhabitants of the region.
In the tympanum above the entrance portal are three sculpted figures forming a crucifixion scene.
In the 16th-century, and additional facade with similar windows and a smaller portal was added on the south.
In 1402, the church was endowed with a gilded silver processional crucifix, attributed to Nicolandrea da Guardagrele.