It stands on a hill, providing an excellent view of Spaccanapoli, a Decumanus of Naples which ends across via Francesco Girardi.

In 1411, a shrine with a statue of the Virgin was converted by the locals into a chapel called Santa Maria d'Ognibene (Holy Mary of all gifts).

After the plague of 1516, the chapel and statue became a convent and church run by the Servite Order.

The church we see now was mainly built starting 1640, by designs of Giovanni Cola Cocco.

The first chapel on right had a Christ heals the lame San Pellegrino Laziosi by Paolo de Matteis, with two lateral paintings by Carlo, the son of Nicola Malinconico.