Santa Maria degli Agonizzanti or Holy Mary of those in agony) is a Baroque-style, Roman Catholic church located on via Giovanni da Procida, just south of Via Roma, in central Palermo, region of Sicily, Italy.

The church was founded in 1630 under the patronage of the Confraternity of Santa Maria degli Agonizzanti, which ministered to those condemned to execution.

This function seems to have shifted in 1799, when executions were performed near the Ponte dell'Ammiraglio, and the decapitated bodies buried in a common fossa in a park that stood in front of the small church, once known as the Madonna del Fiume due to the nearby Oreto River, but presently as the Sanctuario ai Decollati (Sanctuary for the Decapitated).

In the apse are frescoes depicting the Life of the Virgin Mary by Elia Interguglielmi, brother of Antonio.

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