Santa Maria dei Miracoli (English: Holy Mary of the Miracles is a Renaissance-style, Roman Catholic church located in the quarter of Kalsa (Tribunali) of the historic centre of Palermo, region of Sicily, Italy.

Putatively during the festival of Santa Cristina in May, a Marian icon, painted on a wall near this site, was linked to a number of miracles.

In 1547, under the government of the Spanish viceroy of Sicily, Giovanni della Vega, and the archbishop Pietro Tagliavia d'Aragona, and with added patronage of the Florentine community, the church was completed.

In 1629, when the Florentines were expelled from Palermo, the church was granted to the Frati Conventuali of the Franciscan order, who established adjacent a seminary (novitiate) called il Conventino.

The ground floor flanking the portal has two Corinthian columns atop a tall pedestal, surmounted by a small composite pilaster.