Santa Maria della Catena is a Roman Catholic church located in the Piazza Dogana, now sandwiched between Strada Statale 113 and Via Vittorio Emanuele, located in the harbor-hugging quarter of Castellammare in Palermo, region of Sicily, Italy.

The chains were putatively originally a prize acquired from the defeat of a marauding Pisan fleet.

The architecture of the church mixes late Renaissance style and Gothic-Catalan style, the latter especially visible in the three-part arcaded loggia located at the top of the entry staircase (added in 1845).

The interior is also late Gothic, and includes a canvas depicting Nativity with Adoration of the Shepherds (17th century) by an unknown master, and 16th-century bas-reliefs attributed to Vincenzo and Antonello Gagini, who also sculpted the capitals of the columns and the entrance portals.

Annexed to the church is a 1602 convent house, which in 1844 was converted into a state archive.