The church is documented since as early as 1008, and, during the communal period of Arezzo, it was the stronghold of the city's struggle against its bishops.

The church's most striking feature is its façade, with a five-arch lower floor surmounted by three loggias, with the number of columns increasing with the elevation.

The two side portals, of smaller proportions, have also decorated lunettes: they depict "Christ Baptized by John" on the right and, at the left, a vegetable motif.

The tall interior has a nave and two aisles, divided by longitudinal ogival arches whose columns have Corinthian capitals.

At the high altar is the Tarlati polyptych, representing the Madonna and Saints, by Pietro Lorenzetti (1320), while traces of frescoes with St. Dominic and St. Francis (attributed to Andrea di Nerlo, mid-14th century) can be seen inside the church.