By the year 1204, the Oratory of St Bartolomeo di Reno at this site sheltered a venerated icon of the Madonna and Child.
The icon of the Madonna and Child with seven angel heads at the main altar is attributed to the 15th-century painter Michele di Matteo.
The church has three paintings by Agostino Carracci: Adoration by the Shepherds, St Bartolomeo di Reno and the two Prophets in the arch of the chapel.
Also in the sacristy is a Camillo dè Lellis tending to the sick by Dante Bizzotto ((1911–1967); a statue representing St Anthony of Padua and Child Jesus by Giovanni Antonio Raimondi; and an Enthroned Madonna and Child with St Catherine and Lucy by Alessandro Stiatici.
[2] The sanctuary has been recently restored and now owned by the Pii Istituti Educativi (Charitable Educational Institutions).