Santa Maria in Monticelli is a church in the rione of Regola in Rome, sited on the street of the same name.

It was known as Sancta Maria in Monticellis Arenulae de Urbe, in a bull by Urban IV in 1264.

The church was entirely reconstructed in 1716 by Matteo Sassi, on a commission by Clement XI, and in 1860 by Francesco Azzurri.

The church contains a baroque fresco of the Flagellation attributed to Antonio Carracci; a 13th-century painted wooden crucifix attributed to Pietro Cavallini; a Madonna and child with saints by Sebastiano Conca; and a Head of the Redeemer in mosaic fragments of the 12th century.

Near the sanctuary of the church is the contemporary shrine of Blessed César de Bus, the French founder of the "Priests of Christian Doctrine" and the patron saint of catechists.