It is dedicated to Mary, mother of Jesus, and is located on Piazza dei Crociferi in rione Trevi.

In Mariano Vasi's 19th-century guidebook, the church is referred to as Santa Maria a Trevi.

Between 1573 and 1575 the architect Giacomo del Duca rebuilt the church, designing e.g. the innovative pediment above the entrance door.

The altarpiece of St Camillo de Lellis was painted by Gasparo Serenari.

Other altarpieces in side altars were by the studio of Palma il Giovane, Luigi Scaramuccia, and Pietro Perugino.