The facade rises on Via Maqueda, a block north of the central intersection known as the Quattro Canti, in the quarter of Seralcadi, within the historic centre of Palermo.

The order of the Camillians had been founded by the later canonized Camillus de Lellis in 1582, and rapidly spread throughout Italy.

Its adherents, known for wearing cassocks with a red cross, and known as the Crociferi were in demand for their service in ministering to the sick.

The church was open in 1660, but because of financial difficulties, the construction was completed only in 1750 with the conclusion of the façade designed by Ferdinando Lombardo.

Oil on canvas: Panel painting: Frescoes: High reliefs: Statues: The church houses several funeral monuments.