The group was formed in 1989 by singer Rita Guerrero, bassist Alfonso "Poncho" Figueroa, guitarist Pablo Valero and keyboardist Jacobo Lieberman.
The name of the group honors the memory of Maria Sabina, the Mazatec shaman who lived in the southern state of Oaxaca.
There, she met Poncho Figueroa, Pablo Valero and Jacobo Lieberman, who at that time were members of a jazz group called "the Psicotrópicos".
"The Psicotrópicos" agreed to provide music for a play written for Guerrero's theatre class based on Franz Kafka's "Amérika".
Juan Sebastian Lach was the group's keyboard player on all its albums up through "Mar Adentro En La Sangre".
Drummer Patricio Iglesias left the band prior to "Mar Adentro En La Sangre".
Poncho Figueroa organized and produced a tribute album to Mexican rock music pioneer Rodrigo "Rockdrigo" Gonzalez.
Rita Guerrero, lead singer of the band, died on March 11, 2011, due to breast cancer, which was diagnosed in January, 2010.