Santa Sofia is a church located in the sestiere (neighborhood) of Cannaregio in Venice, Italy.

Fontana recounts how in 1836 the church was " redeem(ed) from the Israelites into whose hands it had fallen, and cleared of the debris. "

The main chapel had an altarpiece of Christ preaching to the Masses by Francesco da Ponte.

Other works included altarpieces by Gentile da Fabriano, Lionardo Corona, and Baldassare d'Anna.

[4] In the reduced size of the church after 1836 were housed a Madonna and Saints by Giovanni Battista Maganza; a St Anthony of Padua by Girolamo Brusaferro, a Christ in the Temple and an Adoration of the Magi by Leandro Bassano.

Presently in this church are two paintings by Bassano's school: at the side of the presbytery, and a Baptism of Christ, now attributed to Girolamo Heinz, is now on the main altar.