Santa Sofia dei Tavernieri is a former oratory or small church building located in central Palermo, region of Sicily, Italy.

It is located just off the main street of the city, the ancient Cassaro now Corso Vittorio Emanuele, in the quarter of the Loggia.

This small church was commissioned by the a Lombard confraternity of Tavernieri (inn-keepers).

Over the years, the site became little utilized, including when it became part of a confraternity of the injured victims of war.

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