Construction of the church and convent were directed by Giovan Giacomo di Conforto, while Cosimo Fanzago in 1652 designed the facade with its two stucco statues of Saint Teresa d'Avila and St John of the Cross.

There is also a tomb sculpted by Tito Angelini, statues by Domenico Antonio Vaccaro, busts by Matteo Bottigliero and Angelo Viva and some decorations by Costantino Marassi.

The cupola, designed by Di Conforto, collapsed in 1835 likely due to faulty construction; the replacement has little artistic merit.

After the suppression of the religious orders in 1808, the ornate main altar completed by Dionisio Lazzari was transported to the Capella Reale of the Royal Palace of Naples, where it still can be found.

The altar started in 1672, has two carved lateral doors (1691), a ciborium (1772), all in polychrome pietre dure and lapis lazuli and framed in gilded bronze.