Santalum murrayanum, commonly known as the bitter quandong, is an Australian plant in the sandalwood family, Santalaceae.

[1] It bears a bitter fruit, from which a common name derives, in contrast to congener Santalum acuminatum - sweet quandong.

[2] It occurs in a hemi-parasitic relationship with the roots of several other plants, in a non-destructive way, as with all the species of the genus Santalum.

The shrub or small tree typically grows to a height of 1 to 5 metres (3 to 16 ft).

It is found on sandplains and dunes and has a scattered distribution through the Wheatbelt, Great Southern and Goldfields-Esperance regions of Western Australia where it grows in sandy or gravelly lateritic soils.