Santarpio's Pizza is a restaurant on Chelsea Street in East Boston, Massachusetts, United States.

[2] The restaurant was one of the original pizzerias that opened to cater to Italian Americans who had emigrated to East Boston and the surrounding neighborhoods.

Still owned and operated by the Santarpio family,[3] its menu also features barbecued lamb, steak tips, chicken, and sausage.

Glenn Carlton has baked bread and prepared dough for the pizzas at Santarpio's for 30 years.

Lennie Timpone, whose mother was a Santarpio, was born in 1945 and has worked at the Chelsea Street location his entire life.