Santi Andrea e Bartolomeo is a Catholic church in Rome (Italy), in the Rione Monti, on Via Santo Stefano Rotondo.

Of very ancient origins, its history is linked to that of the hospital of San Giovanni.

During the 14th century the church was completely renovated, then rebuilt between 1630 and 1636 by Giacomo Mola under the pontificate of Urban VIII and finally transformed in eighteenth-century style in 1728, when the facade – which incorporates a fifteenth-century portal – was completed.

[1] The church is almost triangular in shape; the Cosmatesque floor was created by the guardians of the Archconfraternity of the Holy Savior, Marco Diotaiuti and Giovanni Bonadies, in 1462.

It has only one altar at the bottom of the apse and contains a fresco in Byzantine style, which belonged to the chapel (later demolished) of St. Mary the Empress near the monastery of Santi Quattro Coronati.