Santi Cosma e Damiano is a Roman Catholic church in the town of Isernia in the region of Molise, Italy.

A chapel at the hilltop at this site was founded circa 1130, and by the 14th century, a new church was erected dedicated to the Saints Cosmas and Damian (Italian: Santi Cosma e Damiano).

The main altar was built in 1639 and houses a 16th-century canvas depicting the Madonna and Child with Saints and Cardinal Numaio.

[2] The altar of the Virgin of the Addolorata (1744) is to the right of the nave.

[3] This article about a Roman Catholic church building in Italy is a stub.