Santi Gucci's workshop in Pińczów became a notable school that attracted many future artists and became one of the centres of Mannerist art and culture in Poland.
One of the most successful and fruitful artists of his epoch, Gucci built or reconstructed a number of palaces of notable people in all parts of Polish-Lithuanian Commonwealth.
Among them was the Firlej family castle in Janowiec on the Vistula (1565–1585), for whom he also sculpted a Mannerist tomb in a local parish church (c. 1586).
One of his most notable works is the integral design and funerary monuments in the Bartolommeo Berrecci's Sigismund's Chapel in the Wawel Cathedral.
The chapel, often referred to as the pearl of Italian Renaissance north of the Alps, housed the graves of King Sigismund II Augustus and Anna Jagiellon.