[2] These nuns built the small church and the earliest and largest of the two surviving cloisters in the 14th century[2] - that cloister is square in plan and surrounded by a portico of octagonal pilasters supporting a loggiato[4] The complex was handed over to nuns of the order of saint Monica in 1444 and then put under the oversight of the Franciscans in Ascoli in 1481.

[4] A 17th century local historian, Sebastiano Andreantonelli, described the complex as the "seventh convent in Ascoli", still run in his time by the Franciscans.

[6] In 1882 the complex buildings were made the headquarters of the first 'Practical School of Agriculture of Italy' and then in 1924 of the Scuola Media Agraria.

[3] The complex's buildings were then abandoned for a long period but now house the Scuola di Architettura e Design, Unicam.

A 1519 lunette mural of Christ's Climb to Cavalry by Cola dell'Amatrice hangs on the west side of what was the refectory[4] The work belongs to his early period and was restored in the first half of the 19th century after damage by the Napoleonic army.