The deconsecrated church was restored in the year 2000, and the building in 2016 was used for cultural exhibitions and events.
The structure was originally built by a confraternity, Confraternita dell’Annunziata, which had been founded in 1347 by the Beato Cecco and Beata Michelina Metelli to provide for hospice and proper burial to the poor, including pilgrims in transit through Pesaro.
[1] In 1714–1715, the apse acquired a dramatic stucco Annunciation relief by the late-Baroque artist Giuseppe Mazza; this replaced the prior main altarpiece: an early-16th-century painting by Marco Palmezzano, now found in the Pinacoteca Vaticana.
Once this church also housed the Madonna del Popolo with the Beata Michelina, St Luke, and an Angel (now in the Museum of the Cathedral) by Giovanni Giacomo Pandolfi.
[2] The facade once had a revered fresco image of the Madonna del Popolo, but this was removed to protect it from the elements.