The Santo Domingo Church (Spanish: Iglesia de Santo Domingo) is a Dominican church in the historical downtown of Santiago de Chile.

The present structure is the fourth church built on the same site to house the Dominican congregation in Santiago.

[1] The fourth church began to be constructed in 1747 under the design of architect Juan de los Santos Vasconcellos.

The bell towers are constructed of clay brick masonry covered with stucco.

The front facade features pilasters and statues set in niches.