Santo Domingo Petapa is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 232.2 km2, at an average altitude of 250 meters above sea level, and is part of the Juchitán District of the Istmo de Tehuantepec region.

[1] A painting on cotton cloth from 1540 depicts the town and its neighbor Guevea de Humboldt.

The picture records the history of the people from the time of their migration from Zaachila up to the Spanish conquest, and was designed to establish ancient property rights.

The people also grow corn, beans, pineapple, citrus, melon and watermelon, raise cattle, horses, pigs and poultry, and engage in logging.