Santo Domingo Zanatepec is a town and municipality in Oaxaca in south-western Mexico.

It is part of the Juchitán District in the west of the Istmo de Tehuantepec region.

The climate is warm and humid with rain in summer and autumn, averaging 1,220 mm annually.

Wildlife include hare, rabbit, gray fox, coyote, deer, iguana, armadillo and wild birds such as doves, quail and rook.

The main economic activity is cultivation of maize, sorghum, sesame, vegetables and fruit (mango and tamarind).