Santo Domingo Xenacoj is a town, with a population of 10,632 (2018 census),[2] and a municipality in the Guatemalan department of Sacatepéquez.

The native term Xenacoj has been evolving over the centuries: in 1625, Irish friar Thomas Gage, call it Sinacao;[3] later, friar Francisco Ximenes, O.P.

[5] The town was described as having "warm climate" by Irish friar Thomas Gage in his 1648 book about his travels through America in the 1620s and 1630s.

[3] Historian Domingo Juarros wrote that in 1766 the Chimaltenango and Sacatepéquez municipalities tried to join, but it did not work out and they remained split until after independence from Spain in 1821.

[6] Santo Domingo Xenacoj has a subtropical highland climate (Köppen: Cwb).