The church was founded in the 1300s by Cardinal Guglielmo Longo, along with an adjacent hospital and a convent of the Celestine order of Benedictines.
In the fourth chapel is a prominent painting by Lorenzo Lotto of the Madonna and Child with Saints Catherine of Alexandria, Augustine, Sebastian, and Antony Abbot (1521).
It is flanked by two canvases: Daniel in the Lions' Den and Saint Francis Receiving the Stigma by Gian Paolo Cavagna.
In the first chapel on the left is the funeral monument of Agostino and Caterina Tasso and a painting of the Madonna and Child with Saints Peter and Paul and an Angel by Scipione Piazza.
In the second chapel on the left is a polyptych depicting the Descent of the Holy Spirit upon the Madonna and Apostles (1507) by Ambrogio Bergognone.