He became governor of Jalisco when the liberals successfully ousted Antonio López de Santa Anna.
[1] As with a number of rising Liberals, Degollado was not formally trained as a soldier, but gained military experience in the Revolution of Ayutla.
[4] Degollado sought to end the military stalemate and rashly seized a mule-train with nearly a million-pesos' worth of British-owned silver, in order to finance the liberal cause.
"[5] In historian Ralph Roeder's assessment, Degollado's judgment was increasingly flawed, calling on Juárez to resign as constitutional president in order to end the costly and stalemated conflict.
Juárez relieved Degollado of his command, replacing him with López Uraga, who delivered a string of battlefield successes and ultimate victory for the liberals.
[6] When Melchor Ocampo and General Leandro Valle were assassinated in 1861 by conservatives led by General Leonardo Márquez, who remained at large and resorted to guerrilla warfare, Degollado, appointed by Juárez, sought to avenge Ocampo's death, but was also killed by Márquez in his attempt.
His remains were interred at the Panteón de Dolores in Mexico City, in the Rotunda of Illustrious Persons, on November 26, 1936.