Santpoort-Zuid (Dutch pronunciation: [ˌsɑntpoːrt ˈsœyt]; Santpoort South) is a village in the municipality of Velsen in the Dutch province of North Holland.

The village is an upscale neighborhood with Dutch professionals residing there.

It is one of the rare coastal forested areas protected by large dunes.

A famous historic site in Santpoort-Zuid is the Ruin of Brederode, as well as the formerly well-maintained Natuurbad, Velserend.

Santpoort-Zuid is served by Santpoort Zuid railway station.