[11][3] In September 2022, she graduated from the University of Nottingham with a Postgraduate Diploma in Public Procurement law and Policy.
[12] She worked briefly with the Office of the Attorney General for the District of Columbia, Washington DC in the United States and thereafter returned to Ghana.
[14] She was appointed Minister of State in charge of Government Procurement in 2017, serving till 2021,[15] under Nana Addo Dankwa Akufo-Addo, 5th president of the 4th Republic of Ghana.
In the eighth parliament under the fourth Republic of Ghana, Akufo-Addo appointed her as the Minister for Gender, Children and Social Protection.
[16][17][18][19] Adwoa Safo is a member of New Patriotic Party and represent Dome Kwabenya constituency in the 6th, 7th and Eighth Parliament of the Fourth Republic of Ghana.
[21] Adwao Safo was re-elected as a member of parliament for Dome Kwabenya constituency on the ticket of New Patriotic Party in the 2016 Ghanaian general election with 63,488 votes representing 67.99%.
[23] [24][25] She lost in the 2024 NPP parliamentary primaries to Micheal Oquaye Jnr who obtained 1,194 votes against 328 by Adwoa.