1JDM6588n/aENSG00000170290n/aO00631n/aNM_003063n/aNP_003054n/aSarcolipin is a micropeptide protein that in humans is encoded by the SLN gene.

The SLN gene encodes a small transmembrane proteolipid that regulates several sarcoplasmic reticulum Ca2+-ATPases by reducing the accumulation of Ca2+ in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis.

Sarcolipin is an important mediator of muscle based non shivering thermogenesis (NST).

It causes the sarcoplasmic reticulum Ca2+-ATPases to stop pumping Ca2+ ions but continue futilely hydrolysing ATP, thus releasing the energy as heat.

[6][7] Sarcolipin mediated heat production is very important for many organisms to maintain a warm body.