Highway 165 runs west to east parallel to the boundary of the Pre-Cambrian shield in northern Saskatchewan.

The communities of Sakamayack and Beauval are accessible from the highway.

Recreational sites along the highway include Lac la Plonge Campground at the western end of Lac la Plonge[3] and Jayjay Recreation Site at Jayjay Lake near the intersection with Highway 106.

[4][5] The entire route is within the Northern Saskatchewan Administration District.

It is about 292 km (181 mi) long.