[5] Mudslides and spring flooding were huge road-building and maintenance problems on various stretches of Highway 35, including along the southern portion through the Greater Yellow Grass Marsh and along the Souris River, in the middle section through the Qu'Appelle Valley, and in the northern section by Nipawin and at the Saskatchewan River.

The rolling moraines and valleys of the mixed grassland[7] at its southern end give way to aspen parkland towards the middle section.

[6] Weyburn is located astride the Williston geological Basin which contains oil deposits, and several wells operate in the vicinity.

[14] Off Highway 35, at the north end of Weyburn, is access to the site of the former Souris Valley Mental Health Hospital, which at the time of its construction in the 1920s, was the largest building in the British Commonwealth.

The CanAm Highway was a concept that begun in the 1920s and is an important route for the North American Free Trade Agreement (NAFTA) super corridor connecting Mexico, the United States, and Canada.

At the north end of Archerwill, the highway turns west and follows the southern shore of George Williams Lake.

[25] North of Tisdale, Highway 35 crosses Saskatchewan's tree line into boreal forest en route to Nipawin.

[26] The southern boreal forest is marked by aspen combined with jack pine, tamarack, and white spruce.

Access to the Francois Finlay Hydroelectric Dam Vista Viewpoint is from Highway 35, 5 kilometres (3.1 mi) south of Nipawin.

Highway 35 then skirts along the north-western shore of Tobin Lake to a dead end, giving access to Carroll's Cove Campground and Pruden's Point Resort.

In 1953, a rapid flow landslide destroyed a portion of Highway 35 near Fort Qu'Appelle in the Echo Creek Valley.

[33][34] The construction of the Qu'Appelle River Dam in 1967 helped to eliminate washed out roads and flooded communities downstream.

Twenty-one dams were built in the pioneering days to help with the yearly flooding in the Qu'Appelle Valley.

[7] From south to north:[35] Title: Homestead to Heritage, Author Armley History Book Committee, Publisher Friesen Printers, 1987