The highway is a narrow, paved two-lane road for most of its length.

However, it has not been maintained well, as crude road repairs, potholes, and mud sections are common north of Manitou.

The Manitou Beach town site is at km 6; this section may cause confusion among drivers unfamiliar with the town's layout, as no Highway 365 signage is posted in this area, and there are many opportunities to accidentally exit the actual highway.

It turns east along Township Road 320 and follows the south shore of Little Manitou Lake.

[2] Highway 365 crosses Little Manitou Lake at km 10 and shifts onto Range Road 2250.