Highway 378 is a provincial highway in the Canadian province of Saskatchewan.

It runs from Highway 4 near North Battleford to Highways Highway 3 in Spiritwood, just east of its intersection with Highway 24.

It is about 108 kilometres (67 mi) long.

[1] The highway has the distinction of travelling in both an east-west and north-south direction throughout its entire length.

[clarification needed] From south to north:[2]