It runs from the Ring Road at Regina to Highway 1 and Highway 364 near Balgonie; it is about 22 kilometres (14 mi) long.

The present alignment of Highway 46 used to be the original alignment of Highway 1,[2] but was reverted to a gravel grid road when the Trans-Canada Highway was realigned entering Regina along Victoria Avenue in the 1950s.

[3][4] In the early 1980s, Highway 46 was assigned to the route[5] and was subsequently paved from Regina to Pilot Butte.

[6] In the early 1990s, the highway was paved from Pilot Butte to Balgonie.

[7] The route was decommissioned in the 1930s when Highway 51 was constructed between Kerrobert and Biggar.