Satipo is the largest and easternmost province in the Junín Region, located in the central Amazon rainforest of Peru.

[1] The first inhabitants of the present-day province of Satipo were the Asháninkas, Piros, Amueshas, Nomatsiguengas, Simirinches, Amewakas, Cakintis, among others.

The first Europeans arrived in the province's territory in 1673, when the Franciscans founded Santa Cruz, their first settlement in the area.

President Manuel Prado created the Satipo District as part of the province of Jauja on September 18, 1940.

The district of Satipo was elevated to the provincial status by President Fernando Belaúnde Terry on March 26, 1965.