Sayf al-Din Ghazi (II) ibn Mawdud (Arabic: سيف الدين غازي بن مودود, romanized: Sayf ad-Dīn Ghāzī ibn Mawdūd, died 1180) was a Zangid Emir of Mosul, the nephew of Nur ad-Din Zengi.

Saif had been chosen as the successor under the advice of eunuch ’Abd al-Masih, who wanted to keep the effective rule in lieu of the young emir; the disinherited son of Mawdud, Imad ad-Din Zengi II, fled to Aleppo at the court of Nur ad-Din.

After ousting al-Masih, he put Gümüshtekin, one of his officers, as governor, leaving Saif ud-Din nothing but the nominal title of emir.

The nobles of Damascus, worried by Gümüshtekin's increasing power, offered Saif ud-Din their city, but he could not intervene since he was busy in retaking Mosul.

Later he prepared for another battle at Tell al-Sultan (Arabic: تل سلطان) near Aleppo, where he was also defeated; he went back to Mosul and sent messengers to Saladin offering his alliance, which was accepted.