Sayre Area High School is a rural combined junior–senior high school in Sayre, Pennsylvania, that serves two noncontiguous areas of Bradford County: Litchfield Township and the boroughs of Sayre and South Waverly.

It is the sole junior and senior high school operated by the Sayre Area School District.

[1] Sayre Area High School students may choose to attend the Northern Tier Career Center for training in several areas: construction and mechanical trades (including auto mechanics), practical nursing, commercial driving, cosmetology, and food production management.

[2] The BLaST Intermediate Unit 17 provides the school with a wide variety of services, including specialized education for disabled students, speech and visual disability services, state-mandated training on recognizing and reporting child abuse, criminal background check processing for prospective employees, and professional development for staff and faculty.

The district offers a variety of clubs and activities, as well as an extensive, publicly funded sports program.