The district serves two noncontiguous fragments: the Boroughs of Sayre and South Waverly and Litchfield Township in Bradford County, Pennsylvania.

The district encompasses approximately 33 square miles (85 km2) and, as of school year 2021–2022, provides basic educational services to 958 pupils and employs 65.10 full-time equivalent faculty.

[2] Sayre Area School District teachers went on strike on April 12, 2016, adversely impacting the time period for the state testing of students.

[1] High school students may choose to attend the Northern Tier Career Center for training in: food service, cosmetology; practical nursing; technology; auto mechanics; as well as construction and electric trades.

The BLaST Intermediate Unit IU17 provides the district with a wide variety of services like: specialized education for disabled students; state mandated training on recognizing and reporting child abuse; speech and visual disability services; criminal background check processing for prospective employees and professional development for staff and faculty.