[4] Sayyeshaa made her Hindi film debut with Shivaay (2016), receiving Stardust Award for Superstar of Tomorrow – Female nomination.

[citation needed] She portrayed a medical student opposite Akhil Akkineni.

[citation needed] Times of India noted, "Sayyeshaa is a surprise even though she isn’t given much to do.

She received a Stardust Award for Superstar of Tomorrow – Female nomination for her performance.

[citation needed] Deccan Chronicle stated, "Sayyeshaa looks ravishing and she steals the show with her effortless performance.

[26] Deccan Chronicle mentioned, "Sayyeshaa looks beautiful and hogs the limelight despite limited scope.

"[33] Sayyeshaa portrayed PM's press secretary opposite Suriya in the 2019 film Kaappaan.

"[39] She made her Kannada film debut with Yuvarathnaa opposite Puneeth Rajkumar.

[41] The Hans India wrote, "Sayyeshaa has limited screen space but she looks gorgeous in those brief moments.

"[42] In 2023, Sayyeshaa made a special appearance in the song "Raawadi" for the Tamil film Pathu Thala starring Silambarasan.

[43][44] Sayyeshaa is a prominent celebrity endorser for brands and products including PC Jeweller and Cinthol.