First he married Ecaterina, the daughter of Mihail Racovita voda.

From this marriage he had a son, Alexandru Ghica, hospodar of Wallachia.

Next he married Eufrosina and finally Ruxandra, daughter of George Muruzi and Casandra Ypsilanti.

From his third marriage he had a daughter, Elena, who married Alexandru Callimachi, Prince of Moldavia.

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