miSci was founded in 1934 and its exhibitions and educational programming focus on Science, Technology, Engineering, Art, and Mathematics (STEAM).

As of September 2023[update], the museum's president is Gina C. Gould, PhD; Vice President of Collections and Exhibitions is Chris Hunter; and Director of Grants and Special Events is Peter Gabak.

The projector can show the sky from any location on Earth 100,000 years in the past or in the future.

[2] Also located at miSci is a Challenger Learning Center (CLC), which opened in 2014.

[citation needed] The archives also include 110 radios, 60 televisions, 15,000 patents, 5000 books, and 1000 films.